Endometrial receptivity analysis, Endometrial Receptivity Array or simply ERA, is a genetic test designed to assess the receptivity of the endometrium (the lining of the uterus of a woman) during in vitro fertilization (IVF) to assess the optimal time for embryo implantation. That makes it possible for us to choose the best day to transfer the embryos during the menstrual cycle. This test is a personalized approach to determine the implantation window of a uterus that may vary from one person to another. At Australian Concept Lahore, we conduct this test to minimize the risk of failed implantation.
Ultrasonic and microscopic techniques enable us to appreciate many characteristics of the endometrium, like its thickness, cellular growth, and gland development. However, these direct observational techniques do not provide accurate estimation for receptivity. Thus, ERA is a crucial test in assisted reproductive technology, especially for those with a previous history of multiple implantation failures.
The role of sex hormones, especially estrogen (or estradiol) and progesterone, in endometrial receptivity is pivotal for successful embryo implantation during the menstrual cycle. Estrogen increases the thickness and vascularity of the endometrium. Progesterone promotes the development of endometrial glands, which secrete nutrients and create an optimal environment for embryo attachment. It also inhibits premature uterine contractions, ensuring the embryo remains attached in place. The endometrium undergoes simultaneous morphological and functional changes brought about by both hormones, creating the perfect environment for embryo implantation.
To assess your endometrium’s state before IVF, it’s essential to consider the ERA test in Lahore and get the most accurate window for embryo implantation. Based on the results, your doctor can choose a suitable time that’s highly likely to result in a successful pregnancy.
Many signaling pathways participate in achieving optimal receptivity of the endometrium. For instance,
The most used technique for the ERA test is taking an endometrial tissue biopsy. Either the patient undergoes a standard round of hormone replacement therapy or, in the case of a natural cycle, simply the theoretical time of receptivity is calculated (from LH surge). At that time in the menstrual cycle, the biopsy is taken instead of transferring a frozen embryo. The endometrial lining is scratched to obtain a tissue biopsy sample, which is then kept in a sterile container with strict temperature protocols and sent to the lab for genetic sequencing. Although it may cause some discomfort at the time, it is a minimally invasive procedure where general anesthesia and operation theatre are required only in exceptional cases like for patients with cervical stenosis (narrowing of the pathway used for biopsy). The patient can also request general anesthesia.
At Australian Concept in Lahore, it’s a quick, safe, and viable procedure for patients struggling with repeated IVF failures. We make the process quick and ensure minimal to no discomfort to the patient.
The researchers have identified more than 200 genes associated with receptivity and implantation and categorized the results in 3 different ways.
These results help the doctor to find the receptivity window of every patient. The doctor schedules and customizes the embryo transfer to maximize the chances of a successful pregnancy.
Since the inception of assisted reproductive techniques, the embryo has remained the central focus. In contrast, the maternal endometrium was considered a passive part of the reproductive process. Only good quality and maximum number of embryos mattered. Thus, the efficacy of IVF treatment remained very low.
Personalized Embryo Transfer (PET) guided by ERA has better results for pregnancy and implantation than Frozen Embryo Transfer (FET).
The majority of women undergoing IVF treatment for infertility who stand to benefit from the ERA test are those who, while having high-quality embryos, have experienced several unsuccessful embryo implantation attempts.
Choosing the right IVF center is decisive in the treatment of infertility couples. Any center with experienced IVF specialists, state-of-the-art embryology laboratories, and a highly qualified and professional team of embryologists practicing advanced techniques and covering maximum geographic locations would be the best choice. Australian Concept Infertility Medical Center is state-of-the-art fertility clinic in Pakistan.
Different conditions, such as healthcare providers, current inflation/taxes, and additional services, can cause the cost to vary. However, the ERA test is worth the money because it gives essential information about endometrial receptivity during IVF. 30% of IVF cycles fail due to embryo transfer outside the window of receptivity.
If you have had frequent implantation failures, our IVF specialist in Lahore might recommend an ERA test to figure out the optimal time for embryo implantation. The test can add to the cost of your IVF package. The cost may vary from clinic to clinic and usually depends on the doctor’s expertise, medical infrastructure, and other factors.
Fortunately, at our Lahore infertility center, prices for Endometrial Receptivity Tests are pretty reasonable so that every couple planning to undergo IVF in Lahore won’t be burdened with an ERA test that comes with a whopping price tag.
Australian Concept is the leading infertility treatment provider in Lahore with its branches spread across 15+ cities in Pakistan. We hold 27+ years of experience in offering advanced fertility treatment to couples who are unable to get pregnant naturally. We are equipped with a modern embryology lab that consists of cutting-edge technology, such as an MIRI time-lapse incubator and advanced genetic testing facilities. We have a team of internationally trained and certified embryologists and gynecologists who recommend ERA when it’s absolutely necessary. After carefully reviewing your ERA results, we work with you to figure out the most suitable time for embryo implantation. Book your free consultation with our best gynecologist and get tested for endometrial receptivity in Lahore at the most reasonable price.
The cost varies depending on the clinic you choose and the team’s expertise.
Although it doesn’t guarantee a successful pregnancy, ERA can improve your chances of getting pregnant through IVF by helping your fertility specialist choose the best time for transferring the embryo.
The procedure isn’t painful, though some patients may experience mild cramping or some discomfort.
You can get the results in 2-3 weeks.
Yes, if the cause of your failed IVF cycle was choosing the wrong time for transferring the embryo, ERA can help.
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The Australian Concept Infertility Medical Center Lahore “Australian Concept” was established in 1998 with Australian technical collaboration in Karachi, Pakistan.
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