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PRE-IMPLANTATION GENETIC SCREENING

What is PGS?

PGS means Pre-implantation Genetic Screening which is also referred as Pre-implantation Genetic Testing for Aneuploidy (PGT-A). PGS basically determines an embryo’s chromosomal status by screening all the pairs of chromosomes. It is essential to decide the specific number of chromosomes within an embryo. Sometimes, IVF fails due to abnormal number of chromosomes in an embryo. Aneuploidy is a significant cause of challenges in pregnancy as well as birth. To prevent such circumstances, IVF with PGS and ICSI with PGS is encouraged as it can happen to any embryo however, the chances are of it happening increases with the increase of maternal age. In PGS, all the embryos are carefully assessed in a 12 hours long process.

PGS process | Australian Concept
PGS lab test | Australian Concept

Advantages of PGS

Through PGS, viable embryos can be screened prior to implantation. this assisted reproductive technique is evolving rapidly. There are numerous advantages of PGS test which are mentioned below:

  • PGS increases the likelihood of successful and healthy conception
  • It reduces the risk of miscarriage
  • It lowers the need of implanting more than one embryo to the uterus
  • With PGS, couples can plan and balance their family as it helps in gender selection
  • It helps to prevent the transmission of unknown abnormalities
  • PGS can effectively reduce the cost and time of IVF treatment in long run by decreasing the chances for another attempt

Which Couples should consider a PGS test?

Most often the couples who have an increased risk of having embryos with abnormal number of chromosomes are recommended to go for PGS. However, infertility specialists at Australian Concept Infertility Medical Center advice this test under the following circumstances:

Recurrent Miscarriages:

Women with a history of recurrent miscarriages are recommended to go for PGS testing. Women with more than two miscarriages falls in this category.

Increased Maternal Age:

Women over the age of 35 years are recommended to go for PGS as the chances of aneuploidy increase with maternal age.

Failed IVF Attempts:

The couple who has had failed IVF attempts in the past are recommended to undergo PGS testing to secure their chances of successful pregnancy.

Male Factor Infertility:

The couples, who are struggling with conception due to male factor infertility i.e., poor sperm quality and quantity, are recommended to undergo PGS testing as well.

Other couples who are best candidate for PGS testing are:

  • Couples going for single embryo transfer to avoid multiple pregnancies
  • Couples desiring a healthy baby

PGS Overview

Pre-implantation Genetic Screening is a test that is conducted for the genetic study of an embryo developed through an IVF treatment. The main objective of a PGS test is to help a couple in having a normal and healthy baby. It helps in identifying chromosomal abnormalities therefore, allows the selection of normal embryos for implantation. PGS test is carried out on an embryo prior to its implantation into the uterus. It ensures that the embryo is free from aneuploidies hence, results in healthy baby. Besides, it also boosts pregnancy rates and lessens the time required to achieve pregnancy.

Embryo Biopsy procedure
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Is PGS available in Pakistan

Australian Concept Infertility Medical Center is the leading infertility clinic in Pakistan with highest success rate and largest branch network all over the country. It offers state of the art technology and provides international standard facilities to ensure a successful infertility treatment. we acknowledge that IVF treatment is expensive and most of the times couples can only afford one IVF cycle therefore, we offer PGS and PGD in Pakistan at market competitive rates to ensure the success of our IVF treatments.

Difference between PGS and PGD

PGS stands for Pre-implantation Genetic Screening whereas PGD stands for Pre-implantation Genetic Diagnosis. As evident from their names, both the tests are conducted before the embryo(s) is implanted back to the uterus. In PGS, the embryos are screened to ensure that they are normal and free from aneuploidies. Whereas in PGD, the embryos are screened for known genetic disorders of whom either or both of the partners are potential carriers.

Success Rate of PGS

Everyone’s IVF journey is unique hence, one shoe cannot fit all. A method or technique which is beneficial for one cannot be as beneficial for another. Similar is the case with PGS. While PGS test can bore successful results for some couples, it is not of any benefit for others. About 60% to 70% treatments of IVF with PGS result in success which is similar to an IVF treatment without PGS.