PGS which is also referred as Pre-Implantation Genetic Screening for Aneuploidy (PGT-A). PGS basically determines an embryo’s chromosomal status by screening all the pairs of chromosomes. It is essential to decide the specific number of chromosomes within an embryo. Sometimes, IVF fails due to abnormal number of chromosomes in an embryo. Aneuploidy is a significant cause of challenges in pregnancy as well as birth. To prevent such circumstances, IVF with PGS and ICSI with PGS is encouraged as it can happen to any embryo however, the chances are of it happening increases with the increase of maternal age. In PGS, all the embryos are carefully assessed in a 12 hours long process.
Embarking on an Pre-Implantation Genetic Screening (PGS) cycle at Australian Concept Infertility Center is a structured process designed to optimize the chances of achieving a successful pregnancy. Here’s a detailed breakdown of each stage within an PGS Cycle:
Embarking on the journey of Preimplantation Genetic Screening (PGS) at Australian Concept Infertility Center involves a carefully orchestrated series of stages designed to assess the chromosomal health of embryos and improve the chances of a successful pregnancy. Here is a detailed breakdown of the PGS process:
Cell Biopsy: On Day 5 or Day 6 of development, a small number of cells are carefully biopsied from each embryo.
Preserving Embryo Health: The biopsy process is designed to minimize any potential impact on the health and viability of the remaining embryo.
Based on Genetic Analysis: The results of the chromosomal analysis guide the selection of embryos that are chromosomally balanced and have the highest likelihood of a successful pregnancy.
Reduction of Risk: By transferring embryos without chromosomal abnormalities, the risk of implantation failure and miscarriage is significantly reduced.
Minimally Invasive Procedure: Selected embryos are gently transferred into the uterus during a minimally invasive procedure, guided by ultrasound for precision.
Optimizing Success: The number of embryos transferred is determined based on factors such as the woman’s age, previous fertility history, and the results of chromosomal screening, optimizing the chances of a successful pregnancy.
Thorough Pregnancy Testing: Confirm the success of the PGS-assisted pregnancy through comprehensive testing.
Continued Monitoring: Ultrasound monitoring continues throughout the early stages of pregnancy to track fetal development and ensure a positive outcome.
Most often the couples who have an increased risk of having embryos with abnormal number of chromosomes are recommended to go for PGS. However, infertility specialists at Australian Concept Infertility Medical Center advice this test under the following circumstances:
Women with a history of recurrent miscarriages are recommended to go for PGS testing. Women with more than two miscarriages falls in this category.
Women over the age of 35 years are recommended to go for PGS as the chances of aneuploidy increase with maternal age.
The couple who have failed IVF attempts in the past are recommended to undergo PGS testing to secure their chances of successful pregnancy.
The couples, who are struggling with conception due to male factor infertility i.e., poor sperm quality and quantity, are recommended to undergo PGS testing as well.
Other couples who are best candidate for PGS testing are:
Through PGS, viable embryos can be screened prior to implantation. this assisted reproductive technique is evolving rapidly. There are numerous advantages of PGS test which are mentioned below:
PGS can effectively reduce the cost and time of IVF treatment in long run by decreasing the chances for another attempt
Everyone’s IVF journey is unique hence, one shoe cannot fit all. A method or technique which is beneficial for one cannot be as beneficial for another. Similar is the case with PGS. While PGS test can bore successful results for some couples, it is not of any benefit for others. About 60% to 70% treatments of IVF with PGS result in success which is similar to an IVF treatment without PGS.
32-A, Rojhan Street, Block 5, Kehkashan, Clifton, Next to PRANZO Restaurant, Behind BBQ Tonight, Near BILAWAL Chowrangi, Karachi, Sindh, Pakistan 75600
116 Babar Block, Barkat Market, Near Salaar Center, Lahore, 54000.
3rd Floor, Aklas Plaza, G10 Markaz, Behind Babri Masjid, Sawan Road, Islamabad.
The Australian Concept Infertility Medical Center “Australian Concept” was established in 1998 with Australian technical collaboration in Karachi, Pakistan.